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9a-Fluoro-11b,16a,17a,21-tetrahydroxy-1,4-pregnadiene-3,20-dione 16,17-acetonide

Triamcinolone acetonide

CAS: 76-25-5

Molecular Formula: C24H31FO6

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  5. 9a-Fluoro-11b,16a,17a,21-tetrahydroxy-1,4-pregnadiene-3,20-dione 16,17-acetonide

9a-Fluoro-11b,16a,17a,21-tetrahydroxy-1,4-pregnadiene-3,20-dione 16,17-acetonide - Names and Identifiers

Name Triamcinolone acetonide
Synonyms KENALOG
ARISTODERM
Triamcinolone acetonide
Triamcinolone Acetonide BP98
9a-fluoro-16a-hydroxyprednisolone 16a,17a-acetonide
9a-Fluoro-16a-hydroxyprednisolone 16a,17a-acetonide
9ALPHA-FLUORO-16ALPHA-HYDROXYPREDNISOLONE 16ALPHA,17ALPHA-ACETONIDE
ALPHA-FLUORO-11BETA,16ALPHA,17,21-TETRA-HYDROXYPREGNA-1,4-DIENE-3,20-DIONE
9a-fluoro-11b,16a,17a,21-tetrahydroxy-1,4-pregnadiene-3,20-dione 16,17-acetonide
9a-Fluoro-11b,16a,17a,21-tetrahydroxy-1,4-pregnadiene-3,20-dione 16,17-acetonide
9ALPHA-FLUORO-11BETA,21-DIHYDROXY-16ALPHA,17-ISOPROPYLIDENEDIOXY-1,4-PREGNADIENE-3,20-DIONE
9ALPHA-FLUORO-11BETA,16ALPHA,17ALPHA,21-TETRAHYDROXY-1,4-PREGNADIENE-3,20-DIONE 16,17-ACETONIDE
9-alpha-fluoro-11-beta,21-dihydroxy-16-alpha,17-alpha-isopropylidenedioxypregna-1,4-diene-3,20-dione
CAS 76-25-5
EINECS 200-948-7
InChI InChI=1/C24H31FO6/c1-20(2)30-19-10-16-15-6-5-13-9-14(27)7-8-21(13,3)23(15,25)17(28)11-22(16,4)24(19,31-20)18(29)12-26/h7-9,15-17,19,26,28H,5-6,10-12H2,1-4H3/t15?,16?,17-,19+,21-,22-,23-,24+/m0/s1
InChIKey YNDXUCZADRHECN-JNQJZLCISA-N

9a-Fluoro-11b,16a,17a,21-tetrahydroxy-1,4-pregnadiene-3,20-dione 16,17-acetonide - Physico-chemical Properties

Molecular FormulaC24H31FO6
Molar Mass434.5
Density1.1517 (estimate)
Melting Point274-278°C (dec.)
Boling Point576.9±50.0 °C(Predicted)
Specific Rotation(α)D23 +109° (c = 0.75 in chloroform)
Flash Point302.7°C
Water SolubilitySoluble in DMSO or ethanol. Slightly soluble in water.
Solubility Very slightly soluble in water, slightly soluble in ethanol, soluble in chloroform, slightly soluble in acetone.
Vapor Presure1.04E-15mmHg at 25°C
AppearanceWhite to off-white crystalline powder
ColorWhite to Off-White
Merck9596
pKa12.87±0.10(Predicted)
Storage ConditionRefrigerator
StabilityCombustible. Incompatible with strong oxidizing agents.
Refractive Index1.5980 (estimate)
MDLMFCD00056834
UseFor the adrenal cortex hormone drugs, for neurodermatitis, eczema, psoriasis, Arthralgia, bronchial asthma and other diseases

9a-Fluoro-11b,16a,17a,21-tetrahydroxy-1,4-pregnadiene-3,20-dione 16,17-acetonide - Risk and Safety

Hazard SymbolsT - Toxic
Toxic
Risk Codes61 - May cause harm to the unborn child
Safety DescriptionS53 - Avoid exposure - obtain special instructions before use.
S45 - In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.)
WGK Germany3
RTECSTU3920000
TSCAYes
HS Code29372290
ToxicityLD50 oral in mouse: 5gm/kg

9a-Fluoro-11b,16a,17a,21-tetrahydroxy-1,4-pregnadiene-3,20-dione 16,17-acetonide - Standard

Authoritative Data Verified Data

This product is 9-fluoro-11b, 21-dihydroxy-16a, 17[(1-methylethylidene) BIS (OXY)]-pregnan-1, 4-dien-3, 20-dione. The content of C24H31F06 shall be between 97.0% and 102.0% based on the dry product.

Last Update：2024-01-02 23:10:35

9a-Fluoro-11b,16a,17a,21-tetrahydroxy-1,4-pregnadiene-3,20-dione 16,17-acetonide - Trait

Authoritative Data Verified Data
  • This product is white or off-white crystalline powder; Odorless.
  • This product is dissolved in acetone, slightly soluble in chloroform, slightly soluble in methanol or ethanol, and slightly soluble in water.

specific rotation

take this product, precision weighing, plus dioxane dissolution and quantitative dilution of about 10 mg per lml solution, according to the law (General 0621), the specific rotation was 101 ° to 107 °.

absorption coefficient

take this product, precision weighing, plus ethanol dissolution and quantitative dilution to make a solution containing about 10ug per lml, according to UV-visible spectrophotometry (General 0401), the absorbance was measured at a wavelength of 239nm, and the absorption coefficient was 340 to 370.

Last Update：2022-01-01 11:44:54

9a-Fluoro-11b,16a,17a,21-tetrahydroxy-1,4-pregnadiene-3,20-dione 16,17-acetonide - Differential diagnosis

Authoritative Data Verified Data
  1. in the chromatogram recorded under the content determination item, the retention time of the main peak of the test solution should be consistent with the retention time of the main peak of the reference solution.
  2. The infrared absorption spectrum of this product should be consistent with that of the control (Spectrum set 603).
Last Update：2022-01-01 11:44:55

9a-Fluoro-11b,16a,17a,21-tetrahydroxy-1,4-pregnadiene-3,20-dione 16,17-acetonide - Exam

Authoritative Data Verified Data

fluorine

take this product, check according to law (General 0805), fluorine content should be 4.0% ~ 4.75%.

Related substances

take about 25mg of this product, put it in a 50ml measuring flask, add 35ml of methanol, shake to dissolve, dilute with water to the scale, shake well, as a test solution; take 1ml accurately, put it in a 70% measuring flask, add methanol solution to dilute to the scale, shake, as a control solution. 20 u1 of the test solution and the control solution were respectively injected into the liquid chromatograph, and the chromatogram was recorded to 3.5 times of the retention time of the main component peak. If there are impurity peaks in the chromatogram of the test solution, the area of a single impurity peak shall not be greater than 0.3 times (0.3%) of the area of the main peak of the control solution, the sum of each impurity peak area shall not be greater than 0.8 times (0.8%) of the main peak area of the control solution. The peaks in the chromatogram of the test solution which were 0.01 times smaller than the main peak area of the control solution were ignored.

loss on drying

take this product, dry to constant weight at 105°C, weight loss shall not exceed 1.5% (General rule 0831).

ignition residue

not more than 0.2% (General rule 0841).

selenium

take this product 0.10g, inspection according to law (General 0804), should meet the requirements (0.005%).

Last Update：2022-01-01 11:44:55

9a-Fluoro-11b,16a,17a,21-tetrahydroxy-1,4-pregnadiene-3,20-dione 16,17-acetonide - Content determination

Authoritative Data Verified Data

measured by high performance liquid chromatography (General 0512).

chromatographic conditions and system suitability test

silica gel bonded with eighteen alkyl silane was used as the filler; Methanol-water (525:475) was used as the mobile phase; The detection wavelength was 240nm. Triamcinolone acetonide and triamcinolone were dissolved and diluted with 70% methanol solution to prepare 5ug solutions each in 1 ml. 20u1 was injected into human liquid chromatograph and the chromatogram was recorded, the number of theoretical plates shall not be less than 5000 calculated by triamcinolone acetonide peak, and the separation degree between triamcinolone acetonide peak and triamcinolone acetonide peak shall be greater than 15.

assay

take this product, precision weighing, adding methanol to dissolve and quantitatively dilute to make a solution containing about 30ug per lml, as a test solution, take 20u1 injection of human liquid chromatograph for precision measurement, record the chromatogram; Another triamcinolone acetonide reference substance, the same method for determination. According to the external standard method to calculate the peak area, that is.

Last Update：2022-01-01 11:44:56

9a-Fluoro-11b,16a,17a,21-tetrahydroxy-1,4-pregnadiene-3,20-dione 16,17-acetonide - Category

Authoritative Data Verified Data

adrenocortical hormone drugs.

Last Update：2022-01-01 11:44:56

9a-Fluoro-11b,16a,17a,21-tetrahydroxy-1,4-pregnadiene-3,20-dione 16,17-acetonide - Storage

Authoritative Data Verified Data

light shielding, sealed storage.

Last Update：2022-01-01 11:44:56

9a-Fluoro-11b,16a,17a,21-tetrahydroxy-1,4-pregnadiene-3,20-dione 16,17-acetonide - Triamcinolone Acetonide Injection

Authoritative Data Verified Data

This product is a sterile suspension of triamcinolone acetonide. Triamcinolone acetonide-containing (C24H31F06) shall be between 90.0% and 110.0% of the labeled amount.

trait

This product is a suspension of fine particles. After standing, the fine particles sink and form a uniform Milky White suspension after shaking.

identification

  1. in the chromatogram recorded under the content determination item, the retention time of the main peak of the test solution should be consistent with the retention time of the main peak of the reference solution.
  2. take an appropriate amount of this product (about 50mg equivalent to triamcinolone acetonide), extract with diethyl ether for 2 times, 10ml each time, discard the diethyl ether, separate the water layer, filter, and wash the residue with a small amount of water, dry at 105°C for 1 hour. The dried residue was dissolved in absolute ethanol and diluted to give a solution containing about 12ug per 1 ml, and the absorption maximum was measured by UV-Vis spectrophotometry (General 0401) at a wavelength of Nm.
  3. take an appropriate amount of this product (about 40mg equivalent to triamcinolone acetonide), add 5ml of water, add 10ml of diethyl ether, shake extraction, take the water layer, water bath to dry, the residue is dried under reduced pressure, and determined according to law. The infrared absorption spectrum of this product should be consistent with the spectrum of the control (Spectrum set 603 figure).

examination

  • the pH value should be 5.0 to 7.5 (General 0631).
  • Related substances take this product, shake, take 5ml accurately, put it in a 200ml measuring flask, add an appropriate amount of mobile phase, shake to dissolve triamcinolone acetonide, dilute it to scale with mobile phase, shake well, after filtration, the secondary filtrate was taken as a test solution. Test according to the method under triamcinolone acetonide related substances. If there are impurity peaks in the chromatogram of the test solution, the area of a single impurity peak shall not be greater than 0.5 times (0.5%) of the area of the main peak of the control solution, the sum of each impurity peak area shall not be greater than 1.5 times (1.5%) of the main peak area of the control solution. The peaks in the chromatogram of the test solution which were 0.01 times smaller than the main peak area of the control solution were ignored.
  • particle size take this product, fully shake, take 1 drop, according to particle size determination method (General 0982 first method) check 3 visual field, particles should be less than 15um, the particles below 5mm shall not be less than 70%, and the particles below 10um shall not be less than 97%.
  • the bacterial endotoxin of this product is taken and checked according to law (General rule 1143). The amount of endotoxin per 1 mg of triamcinolone acetonide should be less than 3.0EU.
  • others should comply with the relevant provisions under injection (General 0102).

Content determination

take this product, shake, take 2ml, put it in 50ml measuring flask, add the appropriate amount of methanol, ultrasonic dissolve triamcinolone acetonide, let it cool, dilute it to scale with methanol, shake it well, after filtration, an appropriate amount of the filtrate was accurately taken and quantitatively diluted with methanol to prepare a solution containing about 30ug per 1 ml as a test solution. According to triamcinolone acetonide content determination method under the item of determination, calculation, that is obtained.

category

Same as triamcinolone acetonide.

specification

(l)lml:40mg (2)2ml:80mg

storage

light shielding, closed storage.

Last Update：2022-01-01 11:44:57

9a-Fluoro-11b,16a,17a,21-tetrahydroxy-1,4-pregnadiene-3,20-dione 16,17-acetonide - Triamcinolone Acetonide and Econazole Nitrate Cream

Authoritative Data Verified Data

This product contains triamcinolone acetonide (C24H31F06) should be 90.0% ~ 115.0% of the label amount; Containing econazole nitrate (C18H15C13N20 • HNO3) should be 90.0% ~ 110.0% of the label amount.

trait

This product is white cream.

identification

  1. take about 2g of this product, add 18ml of acetone, shake for 15 minutes, filter, take the filtrate as the test solution; Take the appropriate amount of triamcinolone acetonide and econazole nitrate, triamcinolone acetonide in 1 ml was prepared by adding acetone respectively. A solution of 1 mg and 1 mg of econazole nitrate was used as the Control Solutions (1) and (2). According to the thin layer chromatography (General 0502) test, absorb the above three solutions of 10 u1, respectively, on the same silica gel GF254 thin layer plate, with toluene-ethanol-ethyl acetate-formic acid (55:20:20:5) for the development of the solvent, expand, dry, first set the UV lamp (254nm) under the inspection, then set the saturated iodine vapor in the color, the position and color of the two principal component spots displayed by the test solution should be the same as that of the control solution.
  2. in the chromatogram recorded under the content determination item, the retention time of the two main peaks of the test solution should be consistent with the retention time of the two main peaks of the control solution.
  3. two items (1) and (2) above can be selected as one item.

examination

should comply with the relevant provisions under the term "milk aids" (chapter 0109).

Content determination

  • measured by high performance liquid chromatography (General 0512).
  • chromatographic conditions and system suitability test using octyl silane bonded silica gel as filler; [take 0.94g of sodium hexanesulfonate, add acetonitrile-isopropanol-water-85% Phosphoric acid (140:140:720:1) dissolved and diluted to 1000ml] as mobile phase A, [take sodium hexanesulfonate 0.94g, add methanol-water-85% Phosphoric acid (900:100:1) dissolve and dilute to 1000ml] as mobile Phase B, and perform gradient elution according to the following table; Column temperature is 40 ° C.; Detection wavelength is 227nm. The separation of triamcinolone acetonide peak and econazole peak should meet the requirements.
  • determination method: take 1.25g of this product, weigh it accurately, put it in a 25ml measuring flask, add 2ml of tetrahydrofuran, shake for 1 min to dissolve triamcinolone acetonide and econazole nitrate, and dilute it to the scale with metronidazole, shake well, filter, take the continued filtrate as the test solution, take the continued filtrate 10 u1 accurately, inject human liquid chromatograph, record the chromatogram; Take the triamcinolone acetonide reference about 15.6mg, in a 25ml measuring flask, dissolve in methanol and dilute to the scale, shake well to be used as triamcinolone acetonide reference solution; Another econazole nitrate reference about 12.5mg, in a 25ml measuring flask, add 2ml of triamcinolone acetonide reference solution and 2ml of tetrahydrofuran, dilute with methanol to scale, shake well, measure with the same method, and calculate with peak area according to external standard method.

category

antifungal drugs.

storage

sealed and stored in a cool place.

Last Update：2022-01-01 11:44:58
9a-Fluoro-11b,16a,17a,21-tetrahydroxy-1,4-pregnadiene-3,20-dione 16,17-acetonide
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Product Name: triamcinolone acetonide Request for quotation
CAS: 76-25-5
Tel: 15589503653
Email: sales@octagonchem.com
Mobile: 15589503653
QQ: 2283421579 Click to send a QQ messageSend QQ message
Hangzhou Verychem Science And Technology Co.Ltd
Featured ProductsMultiple Specifications
Product Name: Triamcinolone Acetonide Request for quotation
CAS: 76-25-5
Tel: +86-571-88162785
Email: Lucy@verypharm.com
Mobile: +86-13606544505
QQ: 472954302 Click to send a QQ message
Product List: View Catalog
Nantong Reform Petro-Chemical CO., LTD.
Spot supply
Product Name: Triamcinolone acetonide Request for quotation
CAS: 76-25-5
Tel: +86-17551318830
Email: r@reformchem.com­
Mobile: +86-17551318830
QQ: 3785839865 Click to send a QQ messageSend QQ message
Hubei YoungXin Pharmaceutical Tech Co.,Ltd.
Spot supply
Product Name: Fluocinolone Acetonide Impurity 8 (Fluocinolone Acetonide EP Impurity H）(Triamcinolone Acetonide) Visit Supplier Webpage Request for quotation
CAS: 76-25-5
Tel: 0714-3999186
Email: 2853786052@qq.com
Mobile: 86+15671228036
QQ: 2853786052 Click to send a QQ message
Wechat: 15671228036
Jiangsu Pules Biotechnology Co.,Ltd.
Product Name: Triamcinolone acetonide Request for quotation
CAS: 76-25-5
Tel: 17505222756
Email: pules.cn@gmail.com
Mobile: +86-17551318830
Wechat: 17505222756
Hefei TNJ Chemical Industry Co.,Ltd.
Product Name: Triamcinolone acetonide Request for quotation
CAS: 76-25-5
Tel: 0086-551-65418684
Email: sales@tnjchem.com
　　　　 info@tnjchem.com
Mobile: 0086 189 4982 3763
QQ: 2881500840 Click to send a QQ message
Wechat: 0086 189 4982 3763
WhatsApp: 0086 189 4982 3763
Product List: View Catalog
Shanghai Yuanye Bio-Technology Co., Ltd.
Multiple SpecificationsSpot supply
Product Name: Triamcinolone Acetonide Visit Supplier Webpage Request for quotation
CAS: 76-25-5
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409 Click to send a QQ message
Wechat: 18301782025
SHANDONG OCTAGON CHEMICALS LIMITED
Product Name: triamcinolone acetonide Request for quotation
CAS: 76-25-5
Tel: 15589503653
Email: sales@octagonchem.com
Mobile: 15589503653
QQ: 2283421579 Click to send a QQ messageSend QQ message
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9a-Fluoro-11b,16a,17a,21-tetrahydroxy-1,4-pregnadiene-3,20-dione 16,17-acetonide
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